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Abbreviations : TZD thiazolidinediones, SGLT2 sodium-dependent glucose transporters 2, DPP-4 dipeptidyl peptidase IV, : risk reduction, ?: controversial effects or limited evidence Hypoglycemic agents with clear anti-tumor effects Metformin Metformin is among the most widely prescribed oral hypoglycemic agents in clinical practice

The complexity of dose regimens, the patients perception of administration, and fear of injections may affect the rate of commencing injectable treatment

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As retatrutide is still in clinical development, its full drug interaction profile has not been comprehensively established

Lawsuits describe patients suffering from persistent gastrointestinal symptoms, including severe nausea, vomiting, and impaired stomach emptying
