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Patients with high GLP1R sensitivity may tolerate semaglutide better, while those with strong GIPR responsiveness might do well on tirzepatide

Contact your GP or diabetes team if you experience persistent severe nausea or vomiting, severe abdominal pain, signs of dehydration, hypoglycaemia symptoms, or have concerns about medication effectiveness

[DOI] [PMC free article] [PubMed] [Google Scholar] 53.Aroda V.R., Rosenstock J., Terauchi Y., Altuntas Y., Lalic N.M., Villegas E.C.M., Jeppesen O.K., Christiansen E., Hertz C.L., Belkacem K., et al

Semaglutide (the active ingredient in Ozempic) has a half-life of approximately 7 days, meaning your body takes about a week to metabolize half of each dose

If you rely on antacids for heartburn relief, discuss alternative options or appropriate timing with your healthcare provider
