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How Semaglutide Side Effects Change Over the First Month When you start semaglutide, your gastrointestinal system encounters a new signal to move food more slowly through your stomach and intestines

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Supplementary information Acknowledgements We acknowledge the contributions of the clinical staff of the Intramural Research Program of the National Institute on Drug Abuse, and the Clinical Research Unit of Johns Hopkins Bayview Medical Center, as well as the University of Maryland, Baltimore, a member of the Graduate Partnership Program, National Institutes of Health (NIH)

The body also increases production of hunger hormones like ghrelin and decreases satiety hormones, creating a biological drive to regain lost weight
However, the DDIs mediated by these factors remain poorly understood and require further investigation to ensure that GLP-1 RAs can be safely used with concomitant medications

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