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Metabolism plays a key role in the origin or progression of many diseases, including neurodegenerative diseases, diabetes, and cancer [14]

But, most importantly, we imposed a selection bias in our study population as we only were able to observe a change among those with a second measurement during followup, and the results must be interpreted with this in mind

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The study protocol received approval from Chi Mei Hospitals institutional review board in Tainan, Taiwan

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