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Here are some other options to consider: GLP-1 receptor agonists GLP-1 medications are drugs that copy a hormone your body naturally makescalled GLP-1 (glucagon-like peptide-1) that kicks in after you eat

Compound 27 (IC 50 = 1.12 nM) was the most promising, exhibiting selectivity for DPP-4 over DPP-8/9

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Given the established clinical use of GLP-1RAs for the treatment of T2DM, preclinical and clinical research was centered largely around DR, which suggested the neuropathologic protective effects of GLP-1 are due to downregulation of NF-B, proinflammatory cytokines such as TNF-alpha and IL-1beta, and VEGF

We aimed to systematically retrieve all currently available RCTs of tirzepatide in individuals with type 2 diabetes and synthesise the evidence by means of clinically relevant meta-analyses for outcomes of efficacy and safety