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Most common side effects were gastrointestinal, with 24.5% of participants in the phase 2 obesity trial discontinuing efinopegdutide 10 mg due to AE however when the same dose was used with gradual escalation at the MASLD trial (starting dose 2.4 mg for 4 weeks, then 5 mg for 4 weeks and then 10 mg), only 5.6% of participants discontinued the medication due to AE

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There is also some evidence that cytosolic calcium may be increased via the cAMP second messenger 27

Reducing the concentration of angiotensin II (AngII) (32) can increase renal blood flow, promote sodium excretion and diuresis (33), and regulate blood lipids (34)and blood sugar (35, 36), thereby enhancing vascular endothelial function and delaying the progression of AS (37)

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