list of glp 1 agonist drugs GLP-1 Agonists Explained: Definition, How They Work, Side Effects GLP-1 Medications for Weight Loss

Third, GIP receptor activation has not been shown to cause proliferation and anti-apoptosis

Combination or staged GLP-1 with nutrition therapy Given the existing adherence and cost challenges of GLP-1s coupled with significant weight regain after discontinuation, combination or staged therapy with intensive lifestyle management could promote greater efficacy, cost-effectiveness, and equitable obesity care [3,18,222,[271], [272], [273]]

In animal experiments on such drugs, studies on rodents have found that the GLP-1RAs may promote the development of medullary thyroid carcinoma, but this effect has not been observed in non-human primates [23]

Diabetologia 63 , 221228 (2020)

In contrast, GLP-/GIP dual agonists, while controlling blood sugar, can more comprehensively regulate lipid metabolism and reduce the risk of cardiovascular diseases [138,139]

To understand why a triple agonist outperforms its predecessors, you need to understand what each receptor pathway actually does