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1,2,3,4 The number of people with UC is estimated to be ~224 cases per 100,000 people per year globally, with an annual growth rate of 2%

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ACKNOWLEDGMENTS The authors thank Alison Sherwin, PhD, from Edanz ( for editing a draft of the manuscript

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Seven of the patients developed NAION, one developed a stroke in the retina and the final patient developed swelling in both optic nerves