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Because it is metabolized primarily in the liver without the formation of active metabolites, glipizide is the preferred sulfonylurea in patients with renal disease (40)

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Besides, it improved the lipid profile and reduced blood pressure, i.e., much-improved cardiometabolic outcomes, and even its safety profile was comparable to other GLP-1, GIP, and glucagon receptor agonist classes, with reports of only transient gastrointestinal adverse events that were mild or moderate

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