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Important update: GLP-1s for weight loss are not a covered benefit

However, dose-dependent gastrointestinal effects limit efficacy, so drugs with GLP-1 and GCG pharmacology can also target alternative pathways and may expand the therapeutic index (132)

You may not be a fit if youre pregnant, trying to become pregnant, breastfeeding, have certain gastrointestinal conditions, have a history of specific endocrine cancers, or have other medical factors that make GLP-1 treatment inappropriate

Bottom left, RMSF values plotted on the GLP-1R structure bound to GLP-1 (transparent ribbon)

However, when GLP-1 are used in combination with other hypoglycemic drugs such as insulin, sulfonylureas, etc., the risk of hypoglycemia may increase

Medication storage and handling also differs between the two classes, and this affects long-term convenience