glp-1 receptors in the brain Mechanisms of Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways Appetite and Energy Regulation GLP-1 receptor biology: structure, signaling,

doi: 10.1016/j.ijpharm.2023.123718

Strategy 3: Afternoon Coffee Better Than Morning Why Morning = Worse: Stomach most sensitive in morning Overnight fasting means empty stomach Cortisol already higher in morning (caffeine adds to it) Why Afternoon = Better: Already eaten 2-3 meals Stomach less sensitive Food buffer present Optimal Times: 6am (wake up, empty stomach): WORST 7am (30 min after breakfast): OKAY for some 10am (mid-morning with snack): BETTER 2pm (after lunch): BEST Caveat: Don't drink coffee after 2-3pm (disrupts sleep, which worsens GI symptoms next day)

For tirzepatide (Zepbound) Jastreboff and colleagues reported in the New England Journal of Medicine in 2022 that at maximal doses, the percent of individuals reporting side effects were as follows: Nausea 31.0% Diarrhea 23.0% Vomiting 12.2% Constipation 11.7% Bettge and colleagues conducted a study published in Diabetes, Obesity, and Metabolism in 2017 that showed that individuals who were taking metformin while taking a GLP-1 were more likely to have side effects, especially nausea and vomiting

Aloe vera juice Aloe vera contains anthraquinones, which are natural stimulant laxatives

These effects could undermine placental blood flow and then fetal nutrient supply

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