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Busetto L, Bettini S, Makaronidis J, Roberts CA, Halford JCG, Batterham RL

Early data is not encouraging

For retatrutide, the bacteriostatic water calculations for 10mg vials are a common starting point

In adults with overweight or obesity (without diabetes) the semaglutide 2.4 mg dose produced an average weight reduction of about 15% of baseline body weight over ~68 weeks in the STEP 1 trial, a result that surprised many clinicians because it brought pharmacologic outcomes into a range previously associated with surgical interventions

15,139 The latest guidance from the European Association for the Study of the Liver recommends a 35% weight reduction even in normal-weight patients, though solid histological evidence supporting this is lacking

Clinical evidence shows weight regain begins soon after stopping treatment as appetite and caloric intake increase