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Nausea affects approximately 28% of users at higher doses, while diarrhea impacts around 24%

Ibuprofen can narrow blood vessels and affect how well your kidneys remove fluid and salt

Many patients reduce their activity level once initial rapid weight loss slows, assuming the medication alone will continue driving results

Summary: The half-life of retatrutide is approximately 6 days, based on pharmacokinetic data from Phase 1 and Phase 2 clinical studies, which supports its once-weekly subcutaneous injection regimen

On average, people treated for obesity lost 8.4% of body weight before stopping, then regained 0.5% over the following year
