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A study of 72 adults with obesity found that those with the highest added sugar intake experienced the smallest increase in GLP-1 levels following glucose consumption

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Dysfunction in insulin signaling due to hypoinsulinemia, hyperinsulinemia, or insulin resistance leads to impaired glucose uptake, neurotransmitter imbalance, oxidative stress, mitochondrial dysfunction, ion-channel alterations, neuroinflammation, and disruption of the blood-brain barrier, ultimately enhancing neuronal hyperexcitability and seizure susceptibility

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While some view these medications as transformative advances that legitimize obesity as a treatable disease, others worry that their increasing popularity could undermine longstanding efforts to deconstruct diet culture and promote body positivity