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What makes retatrutide different is that, like tirzepatide, it mimics GLP-1 and GIP but also copies a third hormone called glucagon
Cell 80 , 485500 (2020)
But if you can tolerate mild, temporary skin reactions at the injection site, this should not be a primary deciding factor between the two medications
Vitamin D deserves separate mention because fat loss releases stored vitamin D from adipose tissue, temporarily increasing blood levels, but long-term reduced fat intake can lead to deficiency
Wing RR, Lang W, Wadden TA, et al
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