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Activating those two pathways will give you more weight loss than just one medicine alone, he says

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Emmerich SD et al

This systematic review and meta-analysis included a total number of 33,354 individuals
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GLP-1 acts locally in the GI tract and via the vagus nerve, a key autonomic pathway that, when activated, further slows stomach emptying

In Langer's preclinical mouse work, this turned out to be enormous
