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Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance

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Essa combinao atua de forma integrada para reduzir o apetite e aumentar a saciedade, melhorar a homeostase glicmica e promover maior gasto energtico/termognese por meio da atividade no receptor de glucagon

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Liraglutide had a similar effect but to a slightly lesser extent, which the authors attribute to differences in doses and treatment approach of the two drugs

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