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In CKD, damage to the renal vasculature, interstitium, and glomeruli alters the permeability and diminishes the negative charge of the glomerular basement membrane, thereby allowing proteins, especially albumin, to pass through the glomerular membrane (Figure 1) [40]

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These typically resolve within 8 to 24 hours but can lead to clinically significant complications, including dehydration, acute kidney injury, and electrolyte abnormalities