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Practical Strategies to Maintain Weight Loss Long-Term Beyond medication continuity, three behavioral pillars support durable weight maintenance: consistent protein intake (which preserves muscle during weight loss and enhances satiety), structured eating patterns (avoiding erratic meal timing that can trigger hunger), and regular movement (even light activity maintains metabolic health)

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tirzepatide's GIP activation adds a meaningfully different mechanism

F3) and T2DM status, recognizing the prognostic significance of these factors [1,2]

Also, no significant difference was seen between the exenatide and pooled comparator (placebo and insulin) groups (95% CI: -0.98 to 0.96) [152]