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Whilst these mechanisms are beneficial for diabetes and weight management, they create specific considerations in the perioperative setting that may necessitate temporary discontinuation

[9] Certain medications interfere with B12 absorption, most notably metformin (used for type 2 diabetes), proton pump inhibitors (PPIs), and H2-receptor antagonists when used long-term, as they reduce stomach acid production necessary for B12 release from food proteins

The lowest effective dose is the point