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Interestingly, GLP-1RAs are known to reduce appetite and food intake partly via appetite-inhibitory neurotransmission signaling within the arcuate nucleus [16, 17], possibly resulting in subsequent improvements in insulin resistance and serum lipid profiles (e.g., reduction in triglyceride levels)

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Some of those ripple effects make you lose fluid

Overdose with semaglutide may be associated with gastrointestinal effects such as nausea, vomiting and diarrhoea, which could lead to dehydration

Seek same-day assessment by the multidisciplinary foot care service for any new foot ulceration, signs of infection (redness, warmth, discharge), or sudden changes in foot shape suggesting Charcot arthropathy

PlexusDx recommends checking in with your healthcare provider or a registered dietitian every 46 weeks to confirm that your eating pattern supports both weight loss and overall wellness