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Across clinical trials, the mean steady-state trough concentrations ranged from 73.3 40.0 mcg/mL to 79.9 41.4 mcg/mL for 300 mg administered every 2 weeks and from 173 75.9 mcg/mL to 193 77.0 mcg/mL for 300 mg administered weekly

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The primary criterion for dose increase is inadequate achievement of individualized glycemic targets after a minimum of four weeks at the current dose

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