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Despite the drugs cardiovascular benefits, both trials found no significant difference in retinopathy outcomes between the GLP-1RAs and placebo groups
The underlying concept - that gut microbiome composition and function can influence metabolism - is supported by published research

In this review article, we discuss the mechanistic and clinical synergies that make the combined use of GLP-1RAs and SGLT2is appealing in patients with T2DM

Ozempic (semaglutide) drug summary
Researchers are also exploring new compounds that could help preserve muscle mass during weight loss