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J Neurol Neurosurg Psychiatry 2000
The primary retatrutide literature includes a discovery and preclinical characterization paper in Cell Metabolism (2022), a cryo-electron microscopy structural study in Cell Discovery (2024), a phase 1b multiple-ascending-dose trial in The Lancet (2022), and phase 2 trials reported in the New England Journal of Medicine (2023), The Lancet (2023), and Nature Medicine (2024)

In general, if surgery is indicated then the valve is replaced and not repaired (irradiated valve tissue is fibrotic and calcified) Given increased risk of reoperation, mechanical prostheses may be appealing, especially for younger patients

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Semaglutide and Tirzepatide are two of the most consequential peptides in modern metabolic research

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