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NPY is an orexigenic peptide, while AgRP acts as an antagonist of the melanocortin receptors

The overall magnitude of both slowing of gastric emptying and glucose-lowering were marked but variable and dependent on the baseline rate of gastric emptying and less prominent in those with slow baseline gastric emptying (23)

Diabetologia 47 , 357366 (2004)

Start each meal with protein before moving to vegetables and then carbohydrates

To date, the SURPASS program includes nine ongoing randomized controlled trials in patients with type2 diabetes: SURPASS 1 in monotherapy, SURPASS 2 versus semaglutide, SURPASS 3 versus degludec, SURPASS 4 versus glargine and established CV disease, SURPSS 5 basal insulin add-on, SURPASS AP- Combo versus glargine, and SURPASS-CVOT