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These findings suggest that neither direct release of GLP-1 in the OB from hindbrain PPG neuron projections, nor volume transmission via release of GLP-1 into the ventricles are likely sources of GLP-1 to activate OB GLP-1R

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Of note are two GLP-1 derived peptides, semaglutide and taspoglutide that have distinct clinical profiles

PMID 18084343
