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In the SURMOUNT-1 trial involving adults with obesity or overweight without diabetes, participants achieved mean weight reductions of approximately 15% to 21% over 72 weeks, depending on dose

Payer Action Plan Monitor the Drug Pipeline: At this time, there is no action that payers need to take

Some protocols begin at 0.50mg instead of 0.25mg, which uses 2mg across the 28-day window

Aches typically start around week 4, peak at month 2-3 during the 7.5mg dose transition, and 90% of cases resolve by month 4 with proper hydration and electrolyte management

[see Warnings and Precautions (5.4) ]

Improved liver enzymes: ALT and AST (markers of liver inflammation) typically decrease with treatment