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Diabetes 65(1):3443

( I ) cAMP levels in cell lysates were determined following pretreatment with 100 nM each of GLP-1(2836), scrambled control, or forskolin in siRNA-treated cells (white bars) versus the scrambled siRNA control (gray bars) ( n = 3/group for all cAMP and LDH assays, each in triplicate)

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By facilitating glucose-dependent K ATP channel closure and by enhancing CICR, GLP-1 restores the Ca 2+ signal, thereby allowing GSIS to occur

Obesity and diabetes both treated by GLP-1 drugs are also risk factors for Alzheimers and can cause changes in the brain that look similar to the disease