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In the STEP trials, participants who stopped semaglutide regained approximately 50 percent of their weight loss within 12 months

The concerns largely stem from theoretical mechanisms and isolated case reports rather than robust clinical evidence

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The population was primarily between the ages of 45-64 (51.9%), female (55.5%), white (71.8%), and not Hispanic or Latino (82.9%)

Ischemic optic neuropathy

Glucagon-like peptide-1 receptor activation in the ventral tegmental area decreases the reinforcing efficacy of cocaine