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Weight Regain After Stopping Ozempic, Wegovy, or Zepbound: What the 18-Month Study Really Means Oxford-led research found people who stop GLP-1 drugs like Ozempic regain weight roughly four times faster than those who finished diet-only programs, reaching starting weight in 18 months

Originally developed to help regulate blood sugar levels in people with type 2 diabetes, these medications are now widely used to support sustainable weight loss by reducing appetite, slowing gastric emptying, and improving feelings of fullness