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J Endocrinol 116: 357-362, 1988

In one notable example, the company rejected a CAPA request related to burnt electrodes with air pockets, despite the nonconformance potentially causing "arcing and burning a patient." The rejection was justified because it was "the first-time instance of such an event," even though the issue carried significant patient risk

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Funderburk recommends spacing them at least three months apart

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Muni, MD MSc FRCSC, associate professor and vice chair of Clinical Research in the Department of Ophthalmology and Vision Sciences at the University of Toronto in Canada, and principal investigator of this study explained to Medical News Today