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In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) has licensed specific GLP-1 medications for use only in people who are obese, overweight with related health problems, or have type 2 diabetes

Orforglipron is an investigational oral, non-peptide (small-molecule) GLP-1 receptor agonist developed by Eli Lilly, originating from a Chugai discovery program
However the latter responses are impaired in type 2 diabetes (T2D), where -cell dysfunction plays a major role 3

Role of physical exercise, microbiota and myokines

10.1038/jcbfm.2015.44 J