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A randomized clinical trial comparing the effect of once-daily treatment of liraglutide and once-weekly treatment of semaglutide showed that adult patients treated with semaglutide for 68 weeks showed more than twice the decrease in body weight compared to people treated with liraglutide [80]

That evidence may matter significantly for patients with: Prior heart attack Stroke history Significant cardiovascular risk factors Patients Who Prefer Weekly Rather Than Daily Dosing Some people are actually more consistent with once-weekly routines than with daily medications

These are indirect effects, secondary consequences of the gastrointestinal side effects that tirzepatide is known for

Binge eating disorder (BED) There is currently only one FDA-approved medication for BED: lisdexamfetamine

[DOI] [PubMed] [Google Scholar] 42.Ussher JR, et al

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