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Avoid high-fat meals, large portions, and foods known to cause GI distress independently

In STEP-1 (Wilding et al., NEJM 2021), 68 weeks of once-weekly 2.4 mg semaglutide plus lifestyle intervention produced a mean body-weight reduction of about 15%, versus about 2.4% with placebo a large, clinically meaningful, well-replicated effect

In short

Yuan and a group of other researchers recently published a paper comparing the effectiveness of different GLP-1RAs

This is a common side effect and doesnt mean youre doing something wrong

These higher doses are typically reserved for patients who have plateaued at lower doses despite good dietary and exercise habits