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As presented at the American Diabetes Association Meeting: this randomized phase 2b trial in 230 adults with overweight or obesity shows that aleniglipron, an oral small-molecule GLP1-RA, led to up to 11.3% body-weight loss compared with placebo after 36 weeks of treatment.

Limitations include the post hoc design, lack of multiplicity adjustment, and incomplete capture of background therapy changes

However, there is a paucity ...

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Propensity score fine stratification weighted Cox proportional hazards models were fitted to estimate hazard ratios and 95% confidence intervals (CIs) to estimate the average treatment effect among the treated patients

Discover 5 ways to support your satiety hormones and quieten the "food noise"