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It is often described as a triple hormone receptor agonist because it targets three important receptor systems: GLP-1 receptor GIP receptor Glucagon receptor In simple terms, Retatrutide is designed to interact with biological pathways that may affect hunger, fullness, energy use, and metabolic response

10.1038/ismej.2012.6 4 BiglariN.GazianoI.SchumacherJ.RadermacherJ.PaegerL.KlemmP.et al (2021)

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Numerous reports also emphasize the neuroprotective role of GLP-1 mediated signaling, as it was proven to protect synapses, improve synaptic functions, enhance neurogenesis, protect neurons from oxidative stress, and reduce neuronal apoptosis

McKenzie AL, Athinarayanan SJ, McCue JJ, Adams RN, Keyes M, McCarter JP, Volek JS, Phinney SD, Hallberg SJ