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This CNS GLP-1 system does not seem to be activated by peripherally-secreted (endogenous) GLP-1 and therefore may be distinct from the peripheral GLP-1 system

SURMOUNT-5 was the head-to-head trial against semaglutide (the active ingredient in Wegovy and Ozempic)

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Importantly, the benefits emerged early and were consistent across all patient subgroups, including those with relatively well-controlled diabetes

A: To get the nutrients and energy we require

Effect of Proglucagon-Derived Peptides on Amylase Release from Rat Pancreatic Acini