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CONFLICTS OF INTEREST STATEMENT The authors have no conflicts of interest to declare

The aim of the trial is to investigate the safety, tolerability, pharmacokinetics (the exposure of the trial drug in the body) and pharmacodynamics (the effect of the investigated drug on the body) of insulin 287 in subjects with type 2 diabetes

Getting final results from the test from our laboratory usually takes several days

The fat content delays emptying, and the refined-carbohydrate component spikes glucose and insulin in a way that, on top of GLP-1 activity, produces symptoms some patients describe as feeling shaky and unwell rather than nauseous

This finding was supported by many experimental studies and clinical trials in which insulin succeeded to improve depression symptoms through different mechanisms, including interacting with N -methyl-D-aspartic acid (NMDA) receptors in the hippocampus and by regulating neuronal cell growth and survival [78, 79]

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