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Serious side effects are still very rare, but people who have had medullary thyroid cancer or have a family history of it are not eligible because of the possible risks that come with GLP-1 receptor agonism

This cost differential has enormous implications for treatment duration

For statin intolerance, NICE recommends alternatives including ezetimibe, bempedoic acid, and PCSK9 inhibitors based on cardiovascular risk and LDL-C targets

[DOI] [PubMed] [Google Scholar] 4.Nauck MA, DAlessio DA

Mo1908: glucagon-like peptide-1 receptor agonist use in patients with perianal fistulizing Crohns disease is well tolerated and leads to weight loss and clinical improvement in fistula activity

Approved indications Tresiba is approved for type 1 diabetes and type 2 diabetes