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However, subsequent clinical trials reported high rates of nausea and vomiting, leading to the perception that PYY-based therapies were intrinsically intolerable

More research is warranted in order to further consolidate these findings across different type 2 diabetes mellitus (T2DM) subpopulations, and adequately powered studies with a longer follow-up that would allow the exploration of microvascular and macrovascular complications are needed

Glucagon-Like Peptide-1 receptor agonists, dual GIP/GLP-1 receptor agonist tirzepatide and suicidal ideation and behavior: a systematic review of clinical studies and pharmacovigilance reports

These approaches provide symptomatic relief to patients with PD by alleviating involuntary movements

Most studies showed good reporting quality implying an overall low risk of bias (Supplementary table)

These hepatic improvements, which may be associated with cotadutide's glucagon activity, indicate its potential as a therapeutic option for nonalcoholic steatohepatitis (NASH)