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Nausea that would normally be mild becomes severe

The interaction is most significant during two periods: Treatment initiation: When you first start tirzepatide, the gastric emptying effect is new and your body has not adapted Dose escalation: Each time you increase your tirzepatide dose , the gastric emptying delay intensifies temporarily before your body adjusts Over time, as your body adapts to each dose level, the impact on gastric emptying partially normalizes

The presence of type 2 diabetes is also a factor, as both are effective

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After 2 to 3 weeks at each dose, you will have enough information to optimize your timing specifically for that dose level