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Refer to source data for post-hoc t -test results

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IDF, 2015

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However, long-term efficacy and safety remain to be established, especially concerning metabolic disturbances in advanced disease stages

[1] [11] Reevaluation at three- to six-month intervals allows clinicians to ascertain whether the dose can be reduced or the injection interval extended, reflecting current endocrine guidelines that emphasize the lowest effective estrogen exposure and periodic attempts at cessation once symptoms abate