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Serious side effects may include pancreatitis, gallstones, low blood sugar (hypoglycemia), kidney problems including kidney failure, changes in vision in people with type 2 diabetes, increased resting heart rate, depression or thoughts of suicide

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DPP-4 inhibitors showed neutral MACE outcomes but HHF risks in some studies

Triple hormone-receptor agonist retatrutide for MASLD: a randomised phase 2a trial

Retatrutide belongs to the glucagon-like peptide-1 (GLP-1) drug class, like the widely used Wegovy and Mounjaro, but its mechanism of action differs