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In some cases, temporary dose reduction or pausing dose escalation of the GLP-1 medication may be appropriate while nutritional status is optimized, though this decision should be made collaboratively between patient and provider
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A pilot study subsequently conducted by Holst in collaboration with Mette Zander at Hvidovre Hospital between September 1999 and October 2000 indicated that continuous subcutaneous infusions of synthetic GLP-1 over 6 weeks into patients with quite severe type 2 diabetes dramatically improved their blood sugar control, lowered glycated haemoglobin levels and decreased their body weight
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