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Animal and translational work hints at synergy between estrogen signaling and GLP-1 pathways, raising the possibility that fluctuating sex hormone states (menstrual cycle, menopause, exogenous hormones) may shape both efficacy and side-effect profiles (Vigil et al., 2022

And when this recalibration occurs against a backdrop of hormone disruption, that fat often settles in the abdomen , creating what many women call meno belly. The loss of muscle mass and increase in fat mass translates to more than weight gain

Our Experience At Rheumatologist OnCall, in the past two years, our patients have experienced: Remarkable drops in pain, morning stiffness (even with microdoses) Surge in energy, improved sleep, and confidence Steady, sustainable weight loss Reduced need for or the ability to taper steroids, DMARDs, and biologics For carefully selected patients, GLP-1 therapy has been truly life-changing

The Lancet 368(9548):16961705 Popoviciu MS, Pduraru L, Yahya G, Metwally K, Cavalu S (2023) Emerging role of GLP-1 agonists in obesity: a comprehensive review of randomised controlled trials

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