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If an unacceptable increase in cardiovascular risk was not discharged at the interim analysis, the SURPASS-4 trial was to continue until accrual of 133 participants with MACE-4 occurred

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[38] In the SELECT cardiovascular outcomes trial, a prespecified analysis at 208 weeks (approximately 4 years) showed that once-weekly subcutaneous semaglutide 2.4 mg produced sustained weight loss of -10.2% (versus -1.5% with placebo

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