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Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo

The studies varied in design, patient population, and outcome measures, making direct comparisons challenging

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Cardiometabolic effects of GLP-1(9-36amide) Accumulating evidence indicates that some cardiac effects of GLP-1 (7-36amide) are actually mediated via the DPP-4-generated GLP-1 (9-36amide) and its smaller degradation products and, thus, are independent of GLP-1R signaling

The maximum dose of semaglutide used for the treatment of obesity is 2.8 mg/week (0.4 mg/day), whereas the maximum dose for the treatment of T2DM is 1 mg/week

Compounded semaglutide and compounded tirzepatide have made prescription GLP-1 medications more accessible than ever