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Whats Next: Regulatory filing for weight management: by end of 2025 Submission for type 2 diabetes: expected in 2026 Drug discovered by Chugai, licensed by Lilly in 2018 Implication: Orforglipron could become the first once-daily oral GLP-1 therapy with potent glucose-lowering and weight-loss benefits, potentially disrupting the injectable incretin market.

It also slows down gastric emptying, which is a fancy way of saying food stays in your stomach for a longer period

Gastrointestinal side effects can lead to fluid losses

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What is GLP-1 and Why Should You Care

The majority of patients across all groups those currently on a GLP-1, thinking of it, or who used to take one said "yes." Among those who used to take a GLP-1, 42% said they gained "some" weight back after stopping treatment