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Whereas sample sizes for studies included in the review were larger (Ghrelin: M(N)=23, Med(N)=27

The SELECT cardiovascular outcomes trial showed that semaglutide 2.4 mg significantly reduced major adverse cardiovascular events (heart attack, stroke, and cardiovascular death) in patients with established cardiovascular disease and overweight or obesity, even without type 2 diabetes

GLP-1 RA therapy significantly improved both exercise capacity and HRQoL in individuals with obesity-related HFpEF regardless of diabetes status, but had no effect on these parameters in in HFrEF patients

J Cell Mol Med

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