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n paralel cu formele injectabile, PIONEER 6 (Husain i colab., 2019) a investigat Semaglutide la pacieni cu diabet de tip 2 i risc crescut, iar rezultatele arat c, n ceea ce privete evenimentele cardiovasculare majore, profilul su nu este inferior placebo (non-inferiority), ceea ce reprezint un pas important n evaluarea siguranei variantei orale n context cardiovascular

Aims/hypothesis Metformin is the only approved oral agent for youth with type 2 diabetes but its mechanism of action remains controversial

Compared to patients with minimal or moderate response, super responders were more likely to be younger (mean age 51years versus 55years), female (80% versus 58-65%), and white (90% versus 80%)

GLP-1 oral therapy

The results are strong, consistent, and likely position it as a next step beyond current GLP-1 therapies